Publications

Balalab members in bold

A Three-Dimensional Valve-on-Chip Microphysiological System Implicates Cell Cycle Progression, Cholesterol Metabolism and Protein Homeostasis in Early Calcific Aortic Valve Disease Progression

Ishita Tandon, Alan E. Woessner, Laίs A. Ferreira, Christine Shamblin, Gustavo Vaca-Diez, Amanda Walls, Patrick Kuczwara, Alexis Applequist, Denise F. Nascimento, Swastika Tandon, Jin-Woo Kim, Manuel Rausch, Tomasz Timek, Muralidhar Padala, Michael T. Kinter, Dennis Province, Stephanie D. Byrum, Kyle P. Quinn & Kartik Balachandran

Acta Biomaterialia

2024

A Nasal Airway-on-Chip Model to Evaluate Airflow Pre-Conditioning During Epithelial Cell Maturation at the Air-Liquid Interface

Amanda Coleman Walls, Manon van Vegchel, Abigail Lakey, Hemali Gauri, Joshua Dixon, Laís A. Ferreira, Ishita Tandon & Kartik Balachandran

Biofabrication

2024

Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation

Prashanth Ravishankar, Ishita Tandon & Kartik Balachandran

Cardiovascular Engineering and Technology

2022

Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury In vivo

Celeste S. Dunn*, Laís A. Ferreira*, Sara M. Venier*, Syed F. Ali, Jeffrey C. Wolchok & Kartik Balachandran (*equal contribution)

Neurotrauma Reports

2022

Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves

Asya Ozkizilcik, Fah Sysavanh, Smit Patel, Ishita Tandon & Kartik Balachandran

Annals of Biomedical Engineering

2021

Aortic valve cell microenvironment: Considerations for developing a valve-on-chip

Ishita Tandon, Asya Ozkizilcik, Prashanth Ravishankar & Kartik Balachandran

Biophysics Reviews

2021

Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury

Celeste Dunn, Nasya Sturdivant, Sara Venier, Syed Ali, Jeffrey Wolchok & Kartik Balachandran

Neurotrauma Reports

2021

Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease

Ishita Tandon, Kyle P. Quinn & Kartik Balachandran

Frontiers in Cardiovascular Medicine – Heart Valve Disease

2021

Anisotropic Fiber-Reinforced Glycosaminoglycan Hydrogels for Heart Valve Tissue Engineering

Prashanth Ravishankar, Asya Ozkizilcik, Anushae Husain & Kartik Balachandran

Tissue Engineering Part A

2020

Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model

Ishita Tandon, Shelby Johns, Alan Woessner, Jessica Perez, Delaney Cross, Asya Ozkizilcik, Timothy J. Muldoon, Srikanth Vallurupalli, Muralidhar Padala, Kyle P. Quinn & Kartik Balachandran

BMC Cardiovascular Disorders

2020

Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression

Ishita Tandon, Olivia I. Kolenc, Delaney Cross, Isaac Vargas, Shelby Johns, Kyle P. Quinn & Kartik Balachandran

Scientific Reports

2020

The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model

Ngoc Thien Lam, Ishita Tandon & Kartik Balachandran

Journal of Biological Engineering

2019

Using Dimensionless Numbers to Predict Centrifugal Jet-Spun Nanofiber Morphology

Prashanth Ravishankar, Alex Khang, Melissa Laredo & Kartik Balachandran

Journal of Nanomaterials

2019

Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease

Ishita Tandon, Ngoc Thien Lam & Kartik Balachandran

Advances in Heart Valve Biomechanics

2018

Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling

Jessica Perez, Nancy Diaz, Ishita Tandon, Rachel Plate, Christopher Martindale & Kartik Balachandran

Cardiovascular Engineering and Technology

2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Prashanth Ravishankar, M. Alejandra Zeballos & Kartik Balachandran

Journal of Visualized Experiments

2017

Fabrication of a matrigel–collagen semi-interpenetrating scaffold for use in dynamic valve interstitial cell culture

Ngoc Thien Lam, Hanh Lam, Nasya Sturdivant & Kartik Balachandran

Biomedical Materials

2017

Aortic Valve Mechanobiology – from Organs to Cells

K. Jane Grande-Allen, Daniel Puperi, Prashanth Ravishankar & Kartik Balachandran

Mechanobiology: Exploitation for Medical Benefit

2017

Engineering anisotropic biphasic Janus-type polymer nanofiber scaffold networks via centrifugal jet spinning

Alex Khang, Prashanth Ravishankar, Aditya Krishnaswamy, Patrick K. Anderson, Stephanie G. Cone, Zizhao Liu, Xianghong Qian & Kartik Balachandran

Journal of Biomedical Materials Research Part B

2016

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury

Nasya M. Sturdivant, Sean G. Smith, Syed F. Ali, Jeffrey C. Wolchok & Kartik Balachandran

Scientific Reports

2016

Valve interstitial cell shape modulates cell contractility independent of cell phenotype

Ishita Tandon, Atefeh Razavi, Prashanth Ravishankar, Addison Walker, Nasya M. Sturdivant, Ngoc Thien Lam, Jeffrey C. Wolchok & Kartik Balachandran

Journal of Biomechanics

2016

Valve interstitial cell contractile strength and metabolic state are dependent on its shape

Ngoc Thien Lam, Timothy J. Muldoon, Kyle P. Quinn, Narasimhan Rajaram & Kartik Balachandran

Integrative Biology

2016

The Mechanobiology of Drug-Induced Cardiac Valve Disease

Ngoc Thien Lam & Kartik Balachandran

Journal of Long Term Effects of Medical Implants

2015

Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning

Mohammad R. Badrossamay*, Kartik Balachandran*, Andrew K. Capulli, Holly M. Golecki, Ashutosh Agarwal, Josue A. Goss, Hansu Kim, Kwanwoo Shin & Kevin Kit Parker (*equal contribution)

Biomaterials

2014

Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT2A receptor-dependent pathway

Kartik Balachandran, Samiya Hussain, Choon-Hwai Yap, Muralidhar Padala, Adrian H. Chester & Ajit P. Yoganathan

Cardiovascular Pathology

2011

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve

Kartik Balachandran, Patrick W. Alford, Jill Wylie-Sears & Kevin Kit Parker

Proceedings of the National Academy of Sciences

2011

Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification

Kartik Balachandran, Philippe Sucosky & Ajit P. Yoganathan

International Journal of Inflammation

2011

Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness

Kartik Balachandran*, Marina A. Bakay*, Jeanne M. Connolly, Xuemei Zhang, Ajit P. Yoganathan & Robert J. Levy (*equal contribution)

Annals of Thoracic Surgery

2011

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner Author links open overlay panel

Kartik Balachandran, Philippe Sucosky, Hanjoong Jo & Ajit P. Yoganathan

American Journal of Pathology

2010

Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps

Ismail El-Hamamsy*, Kartik Balachandran*, Magdi H. Yacoub, Louis M. Stevens, Padmini Sarathchandra, Patricia M. Taylor, Ajit P. Yoganathan & Adrian H. Chester (*equal contribution)

Journal of the American College of Cardiology

2009

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

Kartik Balachandran, Philippe Sucosky, Hanjoong Jo & Ajit P. Yoganathan

American Journal of Physiology: Heart and Circulatory Physiology

2009

An Ex Vivo Study of the Biological Properties of Porcine Aortic Valves in Response to Circumferential Cyclic Stretch

Kartik Balachandran, Suchitra Konduri, Philippe Sucosky, Hanjoong Jo & Ajit P. Yoganathan

. Annals of Biomedical Engineering

2006

Mechanobiology & Soft Materials Laboratory

Publications

A Three-Dimensional Valve-on-Chip Microphysiological System Implicates Cell Cycle Progression, Cholesterol Metabolism and Protein Homeostasis in Early Calcific Aortic Valve Disease Progression

A Nasal Airway-on-Chip Model to Evaluate Airflow Pre-Conditioning During Epithelial Cell Maturation at the Air-Liquid Interface

Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation

Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury In vivo

Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves

Aortic valve cell microenvironment: Considerations for developing a valve-on-chip

Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury

Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease

Anisotropic Fiber-Reinforced Glycosaminoglycan Hydrogels for Heart Valve Tissue Engineering

Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model

Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression

The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model

Using Dimensionless Numbers to Predict Centrifugal Jet-Spun Nanofiber Morphology

Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease

Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Fabrication of a matrigel–collagen semi-interpenetrating scaffold for use in dynamic valve interstitial cell culture

Aortic Valve Mechanobiology – from Organs to Cells

Engineering anisotropic biphasic Janus-type polymer nanofiber scaffold networks via centrifugal jet spinning

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury

Valve interstitial cell shape modulates cell contractility independent of cell phenotype

Valve interstitial cell contractile strength and metabolic state are dependent on its shape

The Mechanobiology of Drug-Induced Cardiac Valve Disease

Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning

Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT2A receptor-dependent pathway

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve

Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification

Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner Author links open overlay panel

Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

An Ex Vivo Study of the Biological Properties of Porcine Aortic Valves in Response to Circumferential Cyclic Stretch

Mechanobiology &
Soft Materials
Laboratory